Familiengründung und Ablösung junger Erwachsener in den neuen Bundesländern

Der 'erschreckende' Geburtenrückgang sowie eine zunehmende Jugendarbeitslosigkeit sind zwei hervorstechende Merkmale in den neuen Bundesländern. Diese Entwicklungen treffen in besonderer Weise junge Menschen an der Schwelle des Erwachsenenalters. Die Familienform in welcher der Mensch lebt, seine Position am Arbeitsmarkt und seine Wohnform sind generell wichtige Merkmale der Stationen des biographischen Verselbständigungsprozesses junger Menschen. Um die Entwicklung und die Ablösungsdynamik Jugendlicher in den neuen Bundesländern zu erfassen, greift die vorliegende Studie auf speziell dafür entwickelte Umfragedaten zurück. Die verwendeten Datensätze beruhen auf Erhebungen des DFG geförderten Projekts 'Familienkontext von Jugendlichen und jungen Erwachsenen: Intergenerative sozio-ökonomische Transferbeziehungen im Wandel'. Die Daten zeigen folgenden Trend: Die Verzögerung der Verselbständigungsübergänge in den neuen Bundesländern als teilweise Reaktion auf die unsichere ökonomische Situation. Familiengründungen werden daher 'vertagt'. (pmb

TRA-935: REPAIRING HIGH VOLUME HMA HIGHWAYS WITH PRECAST CONCRETE INLAY PANELS

The pavements which make up Canada’s high volume highways are subjected to some of the most demanding conditions in the world. They must structurally be capable of supporting significant traffic loading, which can exceed an average of 30,000 trucks per day. They must be capable of supporting these loads throughout the wide variety of environmental conditions to which they are exposed, ranging from hot summers to cold winters. In order to achieve service lives which do not necessitate frequent maintenance and repair activities, these pavement structures are required to be very resilient. A complication to constructing the resilient pavement structures is that construction activities on high volume highways are generally limited to over-night construction windows that are six to eight hours long. At the end of this construction window, full traffic must typically be reinstated. Ontario’s Ministry of Transportation (MTO) has a number of high volume highways which have been reaching the end of their service lives prematurely due to deep-seated pavement rutting issues. These highways have previously been rehabilitated using a mill and replace strategy. In response to this issue and the restricted construction windows for rehabilitation operations, a new rehabilitation strategy has been developed for rehabilitating high volume hot mix asphalt (HMA) highways. This strategy is the use of Precast Concrete Inlay Panels (PCIPs) which are placed within a partially milled HMA pavement structure. A trial section of the PCIP strategy has been designed and proposed to the MTO for implementation and this paper outlines the development of the rehabilitation strategy, with specific focus on details produced to address to the unique nature of this rehabilitation strategy. These details include panel support conditions, built in design details, and construction specifications that address various constructability and performance concerns

Receptor for advanced glycation endproducts (RAGE) deficiency protects against MPTP toxicity

Copyright © 2011 Elsevier Inc. All rights reserved.Peer reviewedPublisher PD

EIP-AGRI Focus Group : Precision farming

Final report201

Urinary volatile organic compounds for the detection of prostate cancer

© 2015 Khalid et al.This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The aim of this work was to investigate volatile organic compounds (VOCs) emanating from urine samples to determine whether they can be used to classify samples into those from prostate cancer and non-cancer groups. Participants were men referred for a trans-rectal ultrasound-guided prostate biopsy because of an elevated prostate specific antigen (PSA) level or abnormal findings on digital rectal examination. Urine samples were collected from patients with prostate cancer (n = 59) and cancer-free controls (n = 43), on the day of their biopsy, prior to their procedure. VOCs from the headspace of basified urine samples were extracted using solid-phase micro-extraction and analysed by gas chromatography/mass spectrometry. Classifiers were developed using Random Forest (RF) and Linear Discriminant Analysis (LDA) classification techniques. PSA alone had an accuracy of 62-64% in these samples. A model based on 4 VOCs, 2,6-dimethyl-7-octen-2-ol, pentanal, 3-octanone, and 2-octanone, was marginally more accurate 63-65%. When combined, PSA level and these four VOCs had mean accuracies of 74% and 65%, using RF and LDA, respectively. With repeated double cross-validation, the mean accuracies fell to 71% and 65%, using RF and LDA, respectively. Results from VOC profiling of urine headspace are encouraging and suggest that there are other metabolomic avenues worth exploring which could help improve the stratification of men at risk of prostate cancer. This study also adds to our knowledge on the profile of compounds found in basified urine, from controls and cancer patients, which is useful information for future studies comparing the urine from patients with other disease states